Citrate Synthase, mitochondrial (CISY)
First enzyme of the Krebs cycle

Human (Homo sapiens)
Chimpanzee (Pan troglodytes)				
Rhesus Monkey (Macaca mulatta)
Mouse (Mus musculus)
Cow (Bos taurus)
Chicken (Gallus gallus)
Western clawed frog (Xenopus tropicalis)
Zebrafish (Danio rerio)
Fruit fly (Drosophila melanogaster)
Nematode (Caenorhabditis elegans)				
Yeast (Saccharomyces cervisiae)
Mouse-ear cress (plant) (Arabadopsis thaliana)


>Human
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYG
GMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKE
WAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLP
CVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGS
ALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVL
RKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

>Chimpanzee
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYG
GMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKE
WAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLP
CVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELMRLYLTIHSDHEGGNVSAHTSHLVGS
ALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVL
RKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

>Rhesus_monkey
MKGWGWLALLLGALLGTAWARRSQDLHCGACRALVDELEWEIAQVDPKKTIQMGSFRINPDGSQSVVEVP
YARSEAHLTELLEEICDRMKEYGEQIDPSTHRKNYVRVVGRNGESNELDLQGIRIDSDISGTLKFACESI
VEEYEDELIEFFSREADNVKDKLCSKRTDGGTSKNRDRKGKMDVTNSAEKSRRSPAMALLTAAARLLGTK
NASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSV
LDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGQIPTEEQVSWLSKEWAKRAALPSHVVTM
LDNFPTNLHPMSQLSAAVTALNSESNFARAYAEGISRTKYWELIYEDSMDLIAKLPCIAAKIYRNLYREG
SGIGAIDSNLDWSHNFTNMLGYTDSQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMN
GLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFA
LKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLA
QLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

>Mouse
MALLTAATRLLGAKNSSCLVLAARHASASSTNLKDVLSNLIPKEQARIKTFKQQHGKTVVGQITVDMMYG
GMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKMLPKAKGGEEPLPEGLFWLLVTGQMPTEEQVSWLSRE
WAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGMNRAKYWELIYEDCMDLIAKLP
CVAAKIYRNLYREGSSIGAIDSRLDWSHNFTNMLGYTDPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGS
ALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVL
RKTDPRYSCQREFALKHLPKDPMFKLVAQLYKIVPNILLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLMKFVDSK

>Cow
MALLTAAARLFGAKNASCLVLAARHASASSTNLKDILADLIPKEQTRVKAFRQQHGKTVVGQITVDMMYG
GMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKLLPKAKGGEEPLPEGLFWLLVTGQIPTEEQVSWLSQE
WAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESTFARAYSEGINRTKYWELIYEDSMDLIAKLP
CVAAKIYRNLYREGSSIGAIDPKLDWSHNFTNMLGYTDAQFTELMRLYLTIHSDHEGGNVSAHTSHLVGS
ALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVL
RKTDPRYTCQREFALKHLPQDPMFKLVAQLYKIVPNILLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLMKFVDSKSG

>Chicken
MRGMKGLIYETSVLDPDEGIRFRGFSIPECQKLLPKAAGGEEPLPEGLFWLLVTGEVPTPEQVMHRDPQA
DGLGGVKGGSVSPWLNTVPPLQVSWVSREWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESKF
ARAYAEGINRVKYWEFVYEDAMDLIAKLPCVAAKIYRNLYREGSSIGAIDPNLDWSHNFTNMLGYTDPQF
IELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLAFAAAMNGLAGPLHGLANQEVLLWLTDLQKELGQ
DVSDEKLRDFIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPKDPMFKLVAQLYKIVPNVLLEQ
GKAKNPWPNVDAHSGVLLQVSPGCPLYL

>Frog
MSLITAGRLCARILGAKNSPCALIAARQASSSANLKDVLSDLIPKEQTRIKNFRQQYGKNVIGQITVDMM
YGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKLLPKAPGGEEPLPEGLFWLLVTGEAPSQEQVNWIS
KEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARGYAEGVNKTKYWELIYEDSMDLIAK
LPCVAAKIYRNLYREGSSIGAIDSNLDWSHNFTNMLGYTDPQFTELMRLYLTIHSDHEGGNVSAHTSHLV
GSALSDPYLSFSAAMNGLAGPLHGLANQEVLVWLTSLQKDLGGEVSDEKLRDYIWNTLNSGRVVPGYGHA
VLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMKEMN
YYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLMQLVGSKSG

>Zebrafish
MSFLSISRLAPRLLSSKNAACVVVAARNASASTNLKDVLSDLVPKEQSRIKNFKQQYGKTSIGQITVDMV
YGGMRGVKGLVYETSVLDPDEGIRFRGYSIPECQQLLPKAPGGEEPLPEGLFWLLVTGQVPTEEQVSWLS
KEWAKRAALPSHVVTMLDNFPTNLHPMSQFSAAITALNSESSFARAYSEGVNKAKYWEFVYEDSMDLIAK
LPCVAAKIYRNLYREGSSIGAIDSNLDWSHNFTNMLGYTEPQFTELMRLYLTIHSDHEGGNVSAHTSHLV
GSALSDPYLSFSAAMNGLAGPLHGLANQEVLVWLTALQKELGGEVSDEKMRDYIWNTLKSGRVVPGYGHA
VLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMN
YYTVLFGVSRALGVLAQLVWSRALGFPLERPKSMSTDGLMALVGAKSG

>Fruit_fly
MSLYRISARKLSEAQKLPNVGAYVRMIAADGKSLRDVLAAKVPQEQERVKNFRKQHGATKMGETTIDMMY
GGMRGIKALVTETSVLDADEGIRFRGLSIPECQKVLPAADGGTEPLPEGLFWLLLTGEVPTKSQVQQLSR
EWAERAALPQHVVTMLNNMPTTLHPMSQFAAAVTALNHDSKFAKAYSDGVHKSKYWEYVYEDSMDLIAKL
PVVAATIYCNTYRGGKGSRSIDSSLDWSANFVKMLGYDNAPFTELMRLYLTIHSDHEGGNVSAHTVHLVG
SALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLRKLQKEAGNNPSEEQLKEYIWKTLKSGQVVPGYGHAV
LRKTDPRYTCQREFALKHLPEDETFQLVSKIYKVVPPILTETGKVKNPWPNVDAHSGVLLQYYGMKEMNY
YTVLFGVSRALGVLASLVWDRALGLPIERPKSFSTDLLVKMVQK

>Nematode
MSLSGMAIRRLITKGVIPVCQVAPLSTSAEGSTNLKEVLSKKIPAHNAKVKSFRTEHGSTVVQNVNIDMI
YGGMRSMKGMVTETSVLDPEEGIRFRGYSIPECQKLLPKAKGGEEPLPEAIWWLLCTGDVPSEAQTAAIT
KEWNARADLPTHVVRMLDNFPDNLHPMAQFIAAIAALNNESKFAGAYARGVAKASYWEYAYEDSMDLLAK
LPTVAAIIYRNLYRDGSAVSVIDPKKDWSANFSSMLGYDDPLFAELMRLYLVIHSDHEGGNVSAHTSHLV
GSALSDPYLSFSAAMAGLAGPLHGLANQEVLVFLNKIVGEIGFNYTEEQLKEWVWKHLKSGQVVPGYGHA
VLRKTDPRYECQREFALKHLPNDDLFKLVSTLYKITPGILLEQGKAKNPWPNVDSHSGVLLQYFGMTEMS
FYTVLFGVSRALGCLSQLIWARGMGLPLERPKSHSTDGLIKLALAAKK

>Yeast
MTVPYLNSNRNVASYLQSNSSQEKTLKERFSEIYPIHAQDVRQFVKEHGKTKISDVLLEQVYGGMRGIPG
SVWEGSVLDPEDGIRFRGRTIADIQKDLPKAKGSSQPLPEALFWLLLTGEVPTQAQVENLSADLMSRSEL
PSHVVQLLDNLPKDLHPMAQFSIAVTALESESKFAKAYAQGISKQDYWSYTFEDSLDLLGKLPVIAAKIY
RNVFKDGKMGEVDPNADYAKNLVNLIGSKDEDFVDLMRLYLTIHSDHEGGNVSAHTSHLVGSALSSPYLS
LASGLNGLAGPLHGRANQEVLEWLFALKEEVNDDYSKDTIEKYLWDTLNSGRVIPGYGHAVLRKTDPRYM
AQRKFAMDHFPDYELFKLVSSIYEVAPGVLTEHGKTKNPWPNVDAHSGVLLQYYGLKESSFYTVLFGVSR
AFGILAQLITDRAIGASIERPKSYSTEKYKELVKNIESKL

>Plant
MVFFRSVSAFTRLRSRVQGQQSSLSNSVRWIQMQSSTDLDLKSQLQELIPEQQDRLKKLKSEHGKVQLGN
ITVDMVIGGMRGMTGLLWETSLLDPEEGIRFRGLSIPECQKVLPTAQSGAEPLPEGLLWLLLTGKVPSKE
QVEALSKDLANRAAVPDYVYNAIDALPSTAHPMTQFASGVMALQVQSEFQKAYENGIHKSKFWEPTYEDC
LNLIARVPVVAAYVYRRMYKNGDSIPSDKSLDYGANFSHMLGFDDEKVKELMRLYITIHSDHEGGNVSAH
TGHLVGSALSDPYLSFAAALNGLAGPLHGLANQEVLLWIKSVVEECGEDISKEQLKEYVWKTLNSGKVIP
GYGHGVLRNTDPRYVCQREFALKHLPDDPLFQLVSKLYEVVPPVLTELGKVKNPWPNVDAHSGVLLNHYG
LTEARYYTVLFGVSRSLGICSQLIWDRALGLALERPKSVTMDWLEAHCKKASSA